This program computes, for a nucleic acid duplex, the enthalpy, the
entropy and the melting temperature of the helix-coil
transitions. Three types of hybridisation are possible: DNA/DNA,
DNA/RNA, and RNA/RNA. The program first computes the hybridisation
enthalpy and entropy from the elementary parameters of each Crick's
pair by the nearest-neighbor method. Then the melting temperature is
computed. The set of thermodynamic parameters can be easily changed,
for instance following an experimental breakthrough. Melting was
published in Le Novère N. (2001), Bioinformatics, 17: 1226-1227.
Unbundle the distribution in the proper place (e.g. /usr/local/ or c:\Program
Some pre-compiled binaries are located in the directory BIN. If no binary
suitable for your OS is provided, or if you want to compile the programme
yourself (a good idea), edit the file 'SRC/makefile' to suit your needs
(particularly the default path for the files containing the nearest- neighbor
MELTING(1) Melting user-guide MELTING(1)
melting - nearest-neighbor computation of nucleic acid hybri‐
Melting computes, for a nucleic acid duplex, the enthalpy and
the entropy of the helix-coil transition, and then its melt‐
ing temperature. Three types of hybridisat
melting (4.2h-3) unstable; urgency=low
* Changed the doc-base section according to the new policy.
* Updated my email address.
-- Charles Plessy <email@example.com> Sun, 06 Jul 2008 18:11:48 +0900
melting (4.2h-2) unstable; urgency=low
[ Charles Plessy ]
* Moved the Homepage: field out from the package's description.
* Debian menu transition: updated debian/melting.doc-base.