DIALIGN-TX is a command line tool to perform multiple alignment of protein or
DNA sequences. It is a complete reimplementation of the segment-base approach
including several new improvements and heuristics that significantly enhance
the quality of the output alignments compared to DIALIGN 2.2 and DIALIGN-T.
For pairwise alignment, DIALIGN-TX uses a fragment-chaining algorithm that
favours chains of low-scoring local alignments over isolated high-scoring
fragments. For multiple alignment, DIALIGN-TX uses an improved greedy
procedure that is less sensitive to spurious local sequence similarities.
DIALIGN-TX has been published in Amarendran R. Subramanian, Michael Kaufmann,
Burkhard Morgenstern: Improvement of the segment-based approach for multiple
sequence alignment by combining greedy and progressive alignment strategies,
Algorithms for Molecular Biology 3:6, 2008