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swnew/upd_ann.dat
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ID CO9_FUGRU STANDARD; PRT; 586 AA.
AC P79755;
DT 01-NOV-1997 (REL. 35, CREATED)
DT 01-NOV-1997 (REL. 35, LAST SEQUENCE UPDATE)
DT 01-NOV-1998 (REL. 37, LAST ANNOTATION UPDATE)
DE COMPLEMENT COMPONENT C9 PRECURSOR.
GN C9.
OS FUGU RUBRIPES (JAPANESE PUFFERFISH) (TAKIFUGU RUBRIPES).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; PISCES; GNATHOSTOMATA;
OC OSTEICHTHYES; ACTINOPTERYGII; TETRAODONTIFORMES.
RN [1]
RP SEQUENCE FROM N.A.
RX MEDLINE; 98038993.
RA YEO G.S.H., ELGAR G., SANDFORD R., BRENNER S.;
RL GENE 200:203-211(1997).
CC -!- FUNCTION: C9 IS THE FINAL COMPONENT OF THE COMPLEMENT SYSTEM TO BE
CC ADDED IN THE ASSEMBLY OF THE MEMBRANE ATTACK COMPLEX. IT IS ABLE
CC TO ENTER LIPID BILAYERS, FORMING TRANSMEMBRANE CHANNELS (BY
CC SIMILARITY).
CC -!- SIMILARITY: TO COMPLEMENT FACTORS C6, C7, C8, AND TO PERFORIN.
CC -!- SIMILARITY: CONTAINS 2 TYPE-1 TSP REPEATS.
CC -!- SIMILARITY: CONTAINS 1 EGF-LIKE DOMAIN.
CC -!- SIMILARITY: CONTAINS 1 LDL-RECEPTOR CLASS A DOMAIN.
CC --------------------------------------------------------------------------
CC This SWISS-PROT entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use by non-profit institutions as long as its content is in no way
CC modified and this statement is not removed. Usage by and for commercial
CC entities requires a license agreement (See http://www.isb-sib.ch/announce/
CC or send an email to license@isb-sib.ch).
CC --------------------------------------------------------------------------
DR EMBL; U87241; G1845349; -.
DR PROSITE; PS00279; MAC_PERFORIN; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; FALSE_NEG.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
KW COMPLEMENT PATHWAY; COMPLEMENT ALTERNATE PATHWAY; GLYCOPROTEIN;
KW PLASMA; MEMBRANE ATTACK COMPLEX; CYTOLYSIS; SIGNAL; EGF-LIKE DOMAIN;
KW REPEAT.
FT SIGNAL 1 26 POTENTIAL.
FT CHAIN 27 586 COMPLEMENT COMPONENT C9.
FT REPEAT 36 93 TYPE-1 TSP 1.
FT DOMAIN 94 131 LDL-RECEPTOR CLASS A.
FT DOMAIN 490 524 EGF-LIKE.
FT REPEAT 540 586 TYPE-1 TSP 2.
FT DISULFID 96 108 BY SIMILARITY.
FT DISULFID 103 121 BY SIMILARITY.
FT DISULFID 115 129 BY SIMILARITY.
FT DISULFID 363 389 BY SIMILARITY.
FT DISULFID 494 510 BY SIMILARITY.
FT DISULFID 497 512 BY SIMILARITY.
FT DISULFID 514 523 BY SIMILARITY.
FT CARBOHYD 246 246 POTENTIAL.
FT CARBOHYD 274 274 POTENTIAL.
FT CARBOHYD 354 354 POTENTIAL.
FT CARBOHYD 545 545 POTENTIAL.
SQ SEQUENCE 586 AA; 65197 MW; 40CEB614 CRC32;
MRTEAALQLG FCALCVMLAL LGEGMGRELP DPPAVNCVWS RWAPWSSCDP CTNTRRRSRG
VEVFGQFAGI ACQGSVGDRE YCITNAKCNL PPPRECSDSE FQCESGSCIK LRLKCNGDYD
CEDGSDEDCE PLRKTCPPTV LDTNEQGRTA GYGINILGAD PRMNPFNNDF FNGRCDKVRN
PNTLQLDRLP WNIGVLNYQT LVEETASREI YEDSYSLLRE MLKEMSIKVD AGLSFKFKST
EPSMSNNSLK LDASLEYEKK TMIKDVSELT NIKNKSFMRV KGRLQLSTYR MRSHQLQVAD
EFVAHVKSLP LEYEKGIYYA FLEDYGTHYT KNGKSGGEYE LVYVLNQDTI KAKNLTERKI
QECLKIGIEA EFATTSVQDG KAHAKLNKCD DVTTKSQGDV EGKAVVDNVM TSVKGGSLES
AVTMRAKLNK EGVMDIATYQ NWARTIASAP ALINSEPEPI YMLIPTDIPG ANSRIANLKQ
ATADYVAEYN VCKCRPCHNG GTLALLDGKC ICMCSNLFEG LGCQNFKGDK ARVPAARPAV
TQEGNWSCWS SWSNCQGQKR SRTRYCNTEG VLGAECRGEI RSEEYC
//
ID E2BB_FUGRU STANDARD; PRT; 355 AA.
AC Q90511;
DT 15-JUL-1998 (REL. 36, CREATED)
DT 15-JUL-1998 (REL. 36, LAST SEQUENCE UPDATE)
DT 01-NOV-1998 (REL. 37, LAST ANNOTATION UPDATE)
DE TRANSLATION INITIATION FACTOR EIF-2B BETA SUBUNIT (EIF-2B GDP-GTP
DE EXCHANGE FACTOR) (S20I15).
GN EIF2BB.
OS FUGU RUBRIPES (JAPANESE PUFFERFISH) (TAKIFUGU RUBRIPES).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; PISCES; GNATHOSTOMATA;
OC OSTEICHTHYES; ACTINOPTERYGII; TETRAODONTIFORMES.
RN [1]
RP SEQUENCE FROM N.A.
RX MEDLINE; 96202283.
RA TROWER M.K., ORTON S.M., PURVIS I.J., SANSEAU P., RILEY J.,
RA CHRISTODOULOU C., BURT D., SEE C.G., ELGAR G., SHERRINGTON R.,
RA ROGAEV E.I., ST GEORGE-HYSLOP P.H., BRENNER S., DYKES C.W.;
RL PROC. NATL. ACAD. SCI. U.S.A. 93:1366-1369(1996).
CC -!- FUNCTION: CATALYZES THE EXCHANGE OF EUKARYOTIC INITIATION FACTOR
CC 2-BOUND GDP FOR GTP (BY SIMILARITY).
CC -!- SUBUNIT: COMPLEX OF FIVE DIFFERENT SUBUNITS; ALPHA, BETA, GAMMA,
CC DELTA AND EPSILON (BY SIMILARITY).
CC -!- SIMILARITY: BELONGS TO THE EIF-2B ALPHA/BETA/DELTA SUBUNITS
CC FAMILY.
CC --------------------------------------------------------------------------
CC This SWISS-PROT entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use by non-profit institutions as long as its content is in no way
CC modified and this statement is not removed. Usage by and for commercial
CC entities requires a license agreement (See http://www.isb-sib.ch/announce/
CC or send an email to license@isb-sib.ch).
CC --------------------------------------------------------------------------
DR EMBL; U40756; G1117954; -.
KW INITIATION FACTOR; PROTEIN BIOSYNTHESIS.
SQ SEQUENCE 355 AA; 39129 MW; A1B2DE8A CRC32;
MPGADKEVDL TERIEAFLSD LKRGGSGTGP LRGSSETARE TTALLRRITA QARWSSAGDL
MEIIRKEGRR LIAAQPSETT VGNMIRRVLK IIREEYARSR GSSEEADQQE SLHKLLTSGG
LSEENFRQHF AALRANVIEA INELLTELEG TTDNIAMQAL EHIHSNEVIM TVGRSRTVEA
FLKDAARKRK FHVIVAECAP FCQGHKMATS LSTAGIETTV IADAAIFAVM SRVNKVIIGT
QTVLANGGLR AVNGTHTLAL AAKHHSTPLI VCAPMFKLSP QFPNEEDTFH KFVSPHEVLP
FTEGEILSKV NVHCPVFDYV PPELITLFIS NIGGHAPSYI YRLMSELYHP EDHEL
//
